Running both Google Chrome and its variant, Comodo Dragon. Both exhibit the problem under Vista. Tried the font scaling fix (back to 96dpi with XP style management) and also have the Windows Server 2003 mode in play. No joy. the buttons still don't work. Very annoying. Reinstalling fails to fix this, too. How stupid to run into a problem like this so late in the graphical OS game. Basic buttons with important functionality just stop working? I'm not blaming Google; more likely it's MickeySoft. Either way, it doesn't say good things about the rationality in Windows OS design.

By the way, this problem only popped up on one of my systems recently, implying one upgrade or other (mostly just Windows official patches, in my case) is the culprit.