Im afraid not anymore. Not in the way I'd like to. It would be nice if last tab couldn't close chrome at all. I mean that if I close the last tab it shows me my homepage (speed dial for me but doesnt matter), but after I close my homepage then it closes chrome anyway.

So it goes like "I have 20 pages open and suddenly rush on them with my middle mouse button which closes them, and when I click on the last tab it turns into my homepage and then I accidently click on it again and chrome goes off.
Looking forward for something where the only way to close chrome will be right top corner or alt+f4..